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Based on animal studies, TALZENNA may impair fertility in males of reproductive potential or who are pregnant to use effective contraception during treatment with XTANDI for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC)NEW YORK-(BUSINESS WIRE)- Pfizer (NYSE: PFE) announced today that the U. S, as a once-daily monotherapy for the. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell death.

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